Revuforj is a prescription medicine used to treat adults and children 1 year and older with acute leukemia with a lysine methyltransferase 2A gene (KMT2A) translocation whose disease has come back or has not improved after previous treatment(s).

Taking Revuforj

How to take revuforj

Convenience of an oral medicine you can take at home

Revuforj tablets come in different strengths. Each strength is a different color. Your healthcare provider may prescribe more than 1 strength of Revuforj tablets for you, so it is important that you understand how to take your medicine the right way. Be sure that you understand exactly how many tablets you need to take, and what strengths to take.


Take Revuforj exactly as your healthcare provider tells you to. Do not change your dose or stop taking Revuforj unless your healthcare provider tells you to. Your doctor may keep you on Revuforj for at least 6 months to allow time for a clinical response.

Dosing Instructions:

Revuforj® (revumenib) Twice-Daily Dosing
2 times a day by mouth

Take at about the same time each day (about 12 hours apart)

Revuforj® (revumenib) Without Food
On an empty stomach

In the clinical trial, this was defined as at least 2 hours after a meal and 1 hour before the next meal

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Yellow dotted line

or

Revuforj® (revumenib) With Low-fat Meal
With a low-fat meal

Low-fat meals should be about 400 calories and contain 25% or less fat

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If you miss a dose of Revuforj or did not take it at the usual time, take your dose as soon as possible and at least 12 hours before your next dose.
Do not take 2 doses within 12 hours. Return to your normal scheduled dose the following day.

Find tips on how to set and stick with a Revuforj Routine

Before taking Revuforj, tell your healthcare provider about all of your medical conditions, including if you:

  • have any heart problems, including a condition called long QT syndrome

  • have been told you have low blood levels of potassium or magnesium

  • are pregnant or plan to become pregnant. Revuforj may cause harm to your unborn baby. Talk to your healthcare provider about birth control methods you can use during this time

  • are breastfeeding or plan to breastfeed. It is not known if Revuforj passes into your breast milk. Do not breastfeed during your treatment with Revuforj or for 1 week after your last dose of Revuforj

Image of two medicine bottles Image of two medicine bottles

Tell your healthcare provider about any other medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Revuforj and other medicines may affect each other, causing side effects.

Revuforj tablets

What to know before taking Revuforj tablets:

Revuforj® (revumenib) Bottles With Tablets

Bottles and tablets shown are not actual size.

  • Revuforj tablets come in different strengths—your healthcare provider will prescribe a dose that’s right for you
  • You may be prescribed more than 1 strength of Revuforj tablets
  • For example: if you were prescribed the 270-mg dose, you will need to take a 160-mg tablet and a 110-mg tablet together 2 times a day at the same time each day to reach your full dose
  • Swallow Revuforj tablets whole with a cup of water
  • Do not cut or chew tablets
  • If you are unable to swallow tablets, Revuforj can be crushed and dispersed in water as directed in the Instructions for Use

Instructions for Use video: How to prepare Revuforj for people who are unable to swallow tablets whole

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This Instructions for Use video is a step-by-step guide to show you how to prepare an oral dose of the prescription medicine, Revuforj, for people who are unable to swallow tablets whole.

Prior to preparing your first dose, please consult your healthcare provider and read the Medication Guide, including BOXED WARNING, and Instructions for Use.

As a reminder, it’s important to read the Instructions for Use each time you or your child gets a prescription refill; there may be new information. Also note that this information does not take the place of talking with your healthcare provider about your or your child’s medical condition or treatment.

Before we review the step-by-step instructions, here is some important information you need to know before preparing to break apart the Revuforj tablets in water.

Revuforj tablets broken apart in water should be prepared for people who are unable to swallow whole Revuforj tablets. People who can swallow the tablets whole should NOT cut, chew, or break the tablets apart in water.

It’s important to take or give Revuforj tablets exactly as your healthcare provider tells you to. Do not change your dose or stop taking Revuforj unless your provider tells you to.

Revuforj tablets come in different strengths. Each strength is a different color. Your healthcare provider may prescribe more than 1 strength of Revuforj tablets for you or your child, so it’s important that you understand how to take or give the medicine the right way. Be sure that you understand exactly how many tablets you need to take, and what strengths to take.

Check the expiration date on the Revuforj tablet bottles. Do not use Revuforj if the expiration date on the bottles has passed. Contact your healthcare provider or pharmacist.

For more information about Revuforj tablets, see the Full Prescribing Information, including the Medication Guide and Instructions for Use, enclosed in the box with your prescription.

Now let’s go through the instructions for how to prepare and break apart Revuforj tablets in water, starting with the supplies you will need.

You will need a 20 mL oral syringe to administer the medicine. Oral syringes can look different. The syringe must have markings up through 20 mL. Talk to your pharmacist if you are not sure if you have the correct oral syringe size.

Revuforj tablets should be crushed in a clean and dry pill crusher. You can purchase one at your pharmacy. Talk to your pharmacist if you are not sure if you have the correct type of pill crusher.

You will need room temperature water to dissolve the Revuforj tablets.

You will use a teaspoon to measure the room temperature water.

Lastly, you will need a small plastic or glass cup.

Now that we’ve reviewed the supplies you will need, we’re ready to go through each step for how to prepare and break apart Revuforj tablets in water.

Step 1: Gather and place the Revuforj bottles and supplies on a clean, flat surface. Check your prescribed dose. Count out the strengths and number of Revuforj tablets needed for the prescribed dose. For example, if the prescribed dose is 50 mg twice daily, count out two 25-mg tablets.

Add all the Revuforj tablets to a clean and dry pill crusher. Screw the top of the pill crusher down until it touches the Revuforj tablets. Turn the pill crusher cap back and forth to crush the Revuforj tablets. Continue turning the pill crusher cap back and forth, increasing the crushing pressure on the Revuforj tablets each time. Repeat until all large Revuforj tablet pieces are broken up. The crushed tablets should be like the consistency of flour.

Step 2: Use two teaspoons to measure 10 mL of room temperature water. Add the 10 mL of water to the small cup. It’s important that you add water to the cup first and then add the crushed Revuforj tablets. DO NOT add the crushed Revuforj tablets first followed by the room temperature water.

Step 3: Tip the crushed Revuforj tablets from the pill crusher into the small cup that contains 10 mL of water. Carefully add all the crushed Revuforj tablets to the small cup. Hold the pill crusher upside down over the small cup. Tap the pill crusher to make sure no more crushed Revuforj tablet pieces are left in the pill crusher.

Step 4: Carefully swirl the cup right after adding the crushed Revuforj tablets to the small cup with water. Swirl the small cup every 30 seconds to 1 minute for a total of 5 minutes. The crushed Revuforj tablets in water will look cloudy.

Step 5: Draw up the medicine into the 20 mL oral syringe right away. To do this, first push the plunger of the oral syringe all the way up toward the tip. Next, place the tip of the oral syringe in the small cup. Pull the oral syringe plunger to draw up all of the medicine from the small cup. The medicine must be taken within 2 hours of preparation. Turn the oral syringe upside down and back several times before taking or giving the medicine.

Step 6: The adult or child should sit up straight or stand before taking the medicine. Place the tip of the oral syringe into the mouth against the inside of the cheek. Slowly and gently press down on the plunger to gently squirt the medicine into the mouth.

Allow the adult or child to swallow the medicine. Make sure that no medicine is left in the mouth. The adult or child should remain sitting up straight or standing for 2 to 3 minutes right after receiving a dose of the medicine. If the medicine is vomited or all of the medicine is not swallowed, do not give another dose. Wait until the next scheduled dose.

Step 7: The small cup must be rinsed to make sure the adult or child receives the full dose of Revuforj tablets. Place two teaspoons of room temperature water in the cup, rinsing down the sides. Swirl the water around the sides of the small cup to make sure any remaining crushed Revuforj tablets are mixed with the water.

Step 8: Repeat Step 5 and Step 6 until there isn’t any more medicine left in the small cup.

Now that the medicine has been properly prepared and administered, it’s time to review the instructions for cleaning and storing the oral syringe.

Step 9: Remove the plunger from the barrel of the oral syringe.

Step 10: Rinse the barrel and plunger in warm running water to make sure all the medicine has been removed from the oral syringe. Do not boil the oral syringe.

Step 11: Put the plunger into the barrel of the oral syringe.

Step 12: Hold the oral syringe tip under water and draw warm water into the oral syringe and then squirt it out. Do this several times until all the medicine has been removed and the oral syringe is clean.

Step 13: Remove the plunger from the barrel of the oral syringe. Rinse the barrel and plunger again with warm water.

Step 14: Shake off excess water or wipe off the outside of the plunger and barrel. Place the barrel and plunger on a clean, dry paper towel to dry.

Step 15: Make sure the oral syringe parts are fully dry before putting the plunger back into the barrel of the oral syringe. Store the oral syringe in a clean place until the next use.

Replace the oral syringe if there’s any damage to the barrel, plunger, or tip. If you cannot see the dosage markings or it becomes difficult to move the plunger, it is time for it to be replaced. Throw away the oral syringe in your household trash if it is damaged and use a new 20 mL oral syringe.

The final step is cleaning the pill crusher.

Step 16: Rinse both parts of the pill crusher with water. Shake off excess water or wipe both parts of the pill crusher before placing them on a clean, dry paper towel to dry.

As a reminder, Revuforj tablets should be stored at room temperature between 68°F to 77°F. Keep the tablets in the bottle they come in until you are ready to take them. The Revuforj bottle has a drying agent (called a desiccant) and child-resistant closure. It's important to keep Revuforj and all medicines out of the reach of children.

The information in this video does not take the place of talking with your healthcare provider about your or your child’s medical condition or treatment.

Please read the Full Prescribing Information, including BOXED WARNING, as well as the Medication Guide and Instructions for Use available at Revuforj.com.

How to store Revuforj

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  • Store Revuforj at room temperature between 68°F to 77°F (20°C to 25°C)

  • Keep the tablets in the bottle that it comes in until you are ready to take it

  • The Revuforj bottle has a drying agent (desiccant) and child-resistant closure

  • Keep Revuforj and all medicines out of reach of children

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See top of this page for
How to Take Revuforj

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Before taking or giving Revuforj tablets, it’s important to read the Medication Guide and Instructions for Use to get all the information you need to know

Important Safety Information

What is the most important information I should know about Revuforj?

Revuforj may cause serious side effects, including: Differentiation syndrome: Differentiation syndrome is a serious but common condition that affects your blood cells, which may be life-threatening or lead to death if not treated. Differentiation syndrome has happened as early as 3 days and up to 41 days after starting Revuforj. Tell any healthcare provider caring for you that you are taking a medicine that can cause differentiation syndrome. Call your healthcare provider or go to the nearest hospital emergency room right away if you develop any of the following symptoms of differentiation syndrome while taking Revuforj:

  • fever
  • cough
  • shortness of breath
  • severe headache
  • confusion
  • dizziness or lightheadedness
  • fast weight gain
  • swelling of arms, legs, neck, groin, or underarm area
  • decreased urination

If you develop any of these symptoms of differentiation syndrome, your healthcare provider may start you on a medicine given through a vein (intravenous) called corticosteroids and may monitor you in the hospital.


Changes in electrical activity of your heart called QT prolongation. QT prolongation is a serious but common side effect that can cause irregular heartbeats that can be life-threatening or lead to death. Your healthcare provider will check the electrical activity of your heart with a test called an electrocardiogram (ECG) and will also do blood tests to check your potassium and magnesium levels before and during treatment with Revuforj. Tell your healthcare provider right away if you feel faint, lightheaded, dizzy, or if you feel your heart beating irregularly or fast during treatment with Revuforj.


Before taking Revuforj, tell your healthcare provider about all your medical conditions, including if you:

  • have any heart problems, including a condition called long QT syndrome
  • have been told you have low blood levels of potassium or magnesium
  • are pregnant or plan to become pregnant. Revuforj can harm your unborn baby
  • Your healthcare provider will perform a pregnancy test within 7 days before you start treatment with Revuforj. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Revuforj
  • Females who are able to become pregnant should use effective birth control (contraception) during treatment with Revuforj and for 4 months after the last dose of Revuforj
  • Males who have female partners who are able to become pregnant should use effective birth control during treatment with Revuforj and for 4 months after the last dose of Revuforj
  • Talk to your healthcare provider about birth control methods you can use during this time
  • Revuforj may cause fertility problems in females and males. Talk to your healthcare provider if this is a concern for you
  • are breastfeeding or plan to breastfeed. It is not known if Revuforj passes into your breast milk. Do not breastfeed during your treatment with Revuforj or for 1 week after your last dose of Revuforj

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Revuforj and other medicines may affect each other causing side effects.


The most common side effects of Revuforj include:

  • bleeding (hemorrhage)
  • nausea and vomiting
  • muscle pain
  • infections, including bacterial and viral
  • low white blood cell counts with fever
  • diarrhea
  • changes in liver function tests
  • swelling in the arms and legs
  • decreased appetite
  • constipation
  • tiredness

Your healthcare provider will do blood tests and ECGs before you start and during treatment with Revuforj. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with Revuforj if you develop certain side effects. These are not all the possible side effects of Revuforj. Call your healthcare provider for medical advice about side effects.


You are encouraged to report side effects of prescription drugs to FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.


What is Revuforj?

Revuforj® (revumenib) is a prescription medicine used to treat adults and children 1 year and older with acute leukemia with a lysine methyltransferase 2A gene (KMT2A) translocation whose disease has come back or has not improved after previous treatment(s).


Your healthcare provider will perform a test to make sure that Revuforj is right for you.

It is not known if Revuforj is safe and effective in children less than 1 year of age.


Please see Full Prescribing Information, including BOXED WARNING, and Medication Guide and Instructions for Use.

Important Safety Information

Important Safety Information

What is the most important information I should know about Revuforj?

What is the most important information I should know about Revuforj?

  • Revuforj may cause serious side effects, including: Differentiation syndrome: Differentiation syndrome is a serious but common condition that affects your blood cells, which may be life-threatening or lead to death if not treated. Differentiation syndrome has happened as early as 3 days and up to 41 days after starting Revuforj. Tell any healthcare provider caring for you that you are taking a medicine that can cause differentiation syndrome. Call your healthcare provider or go to the nearest hospital emergency room right away if you develop any of the following symptoms of differentiation syndrome while taking Revuforj: