Revuforj is a prescription medicine used to treat adults and children 1 year and older with acute leukemia with a lysine methyltransferase 2A gene (KMT2A) translocation whose disease has come back or has not improved after previous treatment(s).

Support & Resources

Have an upcoming appointment?

Consider asking your healthcare team these questions if you or your loved one are considering or starting treatment with Revuforj:

  • What makes Revuforj right for me?

  • What do I need to know about my genetic testing results?

  • How is Revuforj different?

  • Is Revuforj covered by my insurance?

  • When and how will I know if Revuforj is working?

  • What side effects do I need to look out for?

  • Are there certain foods or activities to avoid while taking Revuforj?

  • Is it safe to take other medications or supplements while taking Revuforj?

  • How long will I stay on Revuforj?

  • As a caregiver, is there anything specific I should know?

Use the definitions below to help familiarize yourself or others with common medical terms

Acute

Symptoms or signs of a disease that begin and worsen quickly if not treated

Acute lymphoblastic leukemia (ALL)

A fast-growing cancer in which too many lymphoblasts (a type of immature white blood cell) are found in the blood and bone marrow. Also called acute lymphocytic leukemia

Acute myeloid leukemia (AML)

A fast-growing cancer in which too many myeloblasts (a type of immature blood cell) are found in the bone marrow and blood

Anemia

A condition in which the number of red blood cells is below normal, sometimes causing fatigue and shortness of breath

Blast

An immature blood cell

Bone marrow

The soft, spongy tissue in the hollow middle of certain bones of the body. This is where new blood cells are made

Cytopenia

A low number of healthy blood cells in the body

Efficacy

Effectiveness; the ability of a treatment to produce the desired result

Hematologic

Of or relating to blood

Neutropenia

A condition in which there is a low number of neutrophils (a type of white blood cell), so the immune system can’t effectively fight against infection

Refractory

A disease or condition that does not respond to treatment

Relapsed

When a disease, or its signs and symptoms, returns after a period of improvement

Response

An improvement related to treatment

Side effects

Unwanted effects of treatment

Sign

A physical change that can be seen or measured by someone else, such as fever or bleeding

Stem cell

Immature blood cells (also called hematopoietic stem cells) found in the bone marrow and in the blood that can mature into all types of blood cells

Stem cell transplant

A procedure in which a person receives healthy stem cells to replace their own stem cells. A stem cell transplant may be autologous (using a person’s own stem cells that were collected and saved before treatment), or it may be allogeneic (using stem cells from a related or unrelated donor)

Symptom

A change in the body that is noticed by the person who has it, such as pain or fatigue

Targeted therapy

Treatment that uses drugs or other substances to identify and attack certain cancer cells. Targeted therapies tend to affect normal cells less and may cause fewer side effects than other cancer treatments

Thrombocytopenia

A condition in which there is a low number of platelets in the blood, increasing the risk of bruising and bleeding

Transfusion

A procedure in which blood or parts of blood are put into a person’s bloodstream through a vein (intravenous or IV)

Translocation

A genetic change in which a piece of one chromosome (part of a cell that contains genetic information) breaks off and attaches to another chromosome

SyndAccessTM Patient Support

How the SyndAccess support team may be able to help you or your loved one

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Navigate Insurance

SyndAccess nurses can answer questions about insurance and your coverage. Our team can investigate your insurance benefits and assist with the prior authorization process to help you or your loved one start treatment.

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Help Paying for Medication

If you cannot afford your medication, SyndAccess may be able to help. Ask your healthcare team about enrolling and to see if you are eligible for the program.*

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Provide Personalized Support

Our team of SyndAccess nurses are here to answer questions, check in with you, and listen when you need support.

Visit SyndAccess.com or call us at 1-888-567-SYND (7963) to learn more.

  • *All SyndAccess programs are subject to eligibility requirements and changes. Eligible commercially insured patients can apply for copay support through the Revuforj® (revumenib) Copay Program. Must be a US resident or US territory resident with a valid prescription. Restrictions apply.

Support & Advocacy

Find support from the community around you

Whether you’re living with acute leukemia or caring for someone who does, you are not alone. Connecting with the community can provide additional support and resources. Consider contacting these organizations to learn about services and support in your local area. You could even meet others who have walked the path you’re on.

Raising awareness
makes a difference

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April 21:

AML World
Awareness Day

September:

Blood Cancer
Awareness Month

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Important Safety Information

What is the most important information I should know about Revuforj?

Revuforj may cause serious side effects, including: Differentiation syndrome: Differentiation syndrome is a serious but common condition that affects your blood cells, which may be life-threatening or lead to death if not treated. Differentiation syndrome has happened as early as 3 days and up to 41 days after starting Revuforj. Tell any healthcare provider caring for you that you are taking a medicine that can cause differentiation syndrome. Call your healthcare provider or go to the nearest hospital emergency room right away if you develop any of the following symptoms of differentiation syndrome while taking Revuforj:

  • fever
  • cough
  • shortness of breath
  • severe headache
  • confusion
  • dizziness or lightheadedness
  • fast weight gain
  • swelling of arms, legs, neck, groin, or underarm area
  • decreased urination

If you develop any of these symptoms of differentiation syndrome, your healthcare provider may start you on a medicine given through a vein (intravenous) called corticosteroids and may monitor you in the hospital.


Changes in electrical activity of your heart called QT prolongation. QT prolongation is a serious but common side effect that can cause irregular heartbeats that can be life-threatening or lead to death. Your healthcare provider will check the electrical activity of your heart with a test called an electrocardiogram (ECG) and will also do blood tests to check your potassium and magnesium levels before and during treatment with Revuforj. Tell your healthcare provider right away if you feel faint, lightheaded, dizzy, or if you feel your heart beating irregularly or fast during treatment with Revuforj.


Before taking Revuforj, tell your healthcare provider about all your medical conditions, including if you:

  • have any heart problems, including a condition called long QT syndrome
  • have been told you have low blood levels of potassium or magnesium
  • are pregnant or plan to become pregnant. Revuforj can harm your unborn baby
  • Your healthcare provider will perform a pregnancy test within 7 days before you start treatment with Revuforj. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Revuforj
  • Females who are able to become pregnant should use effective birth control (contraception) during treatment with Revuforj and for 4 months after the last dose of Revuforj
  • Males who have female partners who are able to become pregnant should use effective birth control during treatment with Revuforj and for 4 months after the last dose of Revuforj
  • Talk to your healthcare provider about birth control methods you can use during this time
  • Revuforj may cause fertility problems in females and males. Talk to your healthcare provider if this is a concern for you
  • are breastfeeding or plan to breastfeed. It is not known if Revuforj passes into your breast milk. Do not breastfeed during your treatment with Revuforj or for 1 week after your last dose of Revuforj

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Revuforj and other medicines may affect each other causing side effects.


The most common side effects of Revuforj include:

  • bleeding (hemorrhage)
  • nausea and vomiting
  • muscle pain
  • infections, including bacterial and viral
  • low white blood cell counts with fever
  • diarrhea
  • changes in liver function tests
  • swelling in the arms and legs
  • decreased appetite
  • constipation
  • tiredness

Your healthcare provider will do blood tests and ECGs before you start and during treatment with Revuforj. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with Revuforj if you develop certain side effects. These are not all the possible side effects of Revuforj. Call your healthcare provider for medical advice about side effects.


You are encouraged to report side effects of prescription drugs to FDA.
Visit www.fda.gov/medwatch or call 1-800-FDA-1088.


What is Revuforj?

Revuforj® (revumenib) is a prescription medicine used to treat adults and children 1 year and older with acute leukemia with a lysine methyltransferase 2A gene (KMT2A) translocation whose disease has come back or has not improved after previous treatment(s).


Your healthcare provider will perform a test to make sure that Revuforj is right for you.

It is not known if Revuforj is safe and effective in children less than 1 year of age.


Please see Full Prescribing Information, including BOXED WARNING, and Medication Guide and Instructions for Use.

Important Safety Information

Important Safety Information

What is the most important information I should know about Revuforj?

What is the most important information I should know about Revuforj?

  • Revuforj may cause serious side effects, including: Differentiation syndrome: Differentiation syndrome is a serious but common condition that affects your blood cells, which may be life-threatening or lead to death if not treated. Differentiation syndrome has happened as early as 3 days and up to 41 days after starting Revuforj. Tell any healthcare provider caring for you that you are taking a medicine that can cause differentiation syndrome. Call your healthcare provider or go to the nearest hospital emergency room right away if you develop any of the following symptoms of differentiation syndrome while taking Revuforj: